IHEPA: Raising Our Sights

Setting our sights on the stars.

Interleukin (IL)-35 is raising our expectations.

PURPOSE To elucidate and discuss the role of IL-35 in immunity to parasitic and bacterial infections as well as in autoimmunity in terms of its anti-inflammatory properties, we highlight significant findings on this novel member of the IL-12 family. METHODS Studies using genetically deficient mice have greatly enhanced our understanding of the biology of IL-35. On the basis of data derived fr...

Raising the CD4+ initiation threshold with our eyes wide open.

Raising our voices to say who we are.

Sights on cone geometry

JCB • VOLUME 174 • NUMBER 1 • 2006 4 R ather than merely point-to-point dispatches, synaptic messengers also make widespread broadcasts, as evidenced by Steven DeVries, Wei Li, and Shannon Saszik (Northwestern University, Chicago, IL). Messages are received both near and far, they show, to create transient and sustained responses. The cone presynaptic terminal is highly invaginated, with ribbon...